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Generic Name: progesterone Dosage Form: vaginal insert. Medically reviewed by Drugs. Last updated on Sep 1, The dose of Endometrin is mg administered vaginally two or three times daily starting the day after oocyte retrieval and continuing for up to 10 weeks total duration.

Efficacy in women 35 years of age and older has not been clearly established. The appropriate dose of Endometrin in this age group has not been determined. The physician should be alert to earliest signs of myocardial infarction, cerebrovascular disorders, arterial or venous thromboembolism venous thromboembolism or pulmonary embolismthrombophlebitis, or retinal thrombosis. Endometrin should be discontinued if any of these are suspected.

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Patients with a history of depression need to be closely observed. Consider discontinuation if symptoms worsen. Endometrin should not be recommended for use with other vaginal products such as antifungal products as this may alter progesterone release and absorption from the vaginal insert [ see Drug Interactions 7 ]. Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in practice.

The safety data reflect exposure to Endometrin in infertile women Endometrin was studied at doses of mg twice daily and mg three times daily. Other less common reported adverse reactions included vaginal irritation, itching, burning, discomfort, urticaria, and peripheral edema. Endometrin is also expected to have adverse reactions similar to other drugs containing progesterone that may include breast tenderness, bloating, mood swings, irritability, and drowsiness.

No formal drug-drug interaction studies have been conducted for Endometrin. Drugs known to induce the hepatic cytochrome-PA4 system such as rifampin, carbamazepine may increase the elimination of progesterone. The effect of concomitant vaginal products on the exposure of progesterone from Endometrin has not been assessed. Endometrin is not recommended for use with other vaginal products such as antifungal products as this may alter progesterone release and absorption from the vaginal insert [ see Warnings and Precautions 5.

Endometrin has been used to support embryo implantation and maintain clinical pregnancy in one clinical study. The live birth outcomes of these pregnancies were as follows:.

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Birth defects reported in the Endometrin twice daily group included: one fetus with a cleft palate and intrauterine growth retardation, one fetus with spina bifida, three fetuses with congenital heart defects, one fetus with an umbilical hernia, and one fetus with an intestinal anomaly.

Birth defects reported in the Endometrin three times daily group included: one fetus with an esophageal fistula, one fetus with hypospadias and an underdeveloped right ear, one fetus with Down's Syndrome and an atrial septal defect, one fetus with congenital heart anomalies, one fetus with DiGeorge's syndrome, one fetus with a hand deformity, and one fetus with cleft palate. For additional information on the pharmacology of Endometrin and pregnancy outcome information [ see Clinical Pharmacology 12 and Clinical Studies Sections 14 ].

Detectable amounts of progesterone have been identified in the milk of nursing mothers.Prescribing Information.

Comparing Crinone vs Endometrin

Progesterone is one of the hormones essential for helping you to become and to stay pregnant. Available to download or print in the languages below. The usual dose is 1 insert placed in your vagina 2 to 3 times a day for up to a total of 10 weeks, unless your healthcare provider advises otherwise. Common side effects seen with ART and Endometrin included pelvic pain after surgery, abdominal pain, nausea, and swollen ovaries ovarian hyperstimulation syndrome.

Other reported side effects included abdominal bloating, headache, urinary infections, uterine cramping, constipation, vomiting, tiredness, and vaginal bleeding.

Vaginal products with progesterone may also cause vaginal irritation, burning and discharge. For more information, ask your healthcare provider or pharmacist. Tell your healthcare provider if you have any side effect that bothers you or that does not go away.

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It's horrible. If possible, I'm going to try to avoid the shots, so wanted to see if anyone has any experience on Endometrin. If so, did you have any issues on it? I have 5 weeks left from today on progesterone and I honestly don't think I'll make it on Crinone! I used Endometrin and it is pretty nasty. I didn't have any burning or itching though, just some mild irritation and cramping. It leaks out and you have to wear a panty liner unless you want a big wet spot. You will probably start with twice a day and your RE will gradually decrease to once a day, then every other day.

I was on it until 11 weeks. Honestly nearing the end of endometrium it was driving me crazy. Gross discharge, feeling icky down there. I needed to do it 3 times a day. A sore butt for a few weeks would have been better IMO. I used Endometrin but never PIO. I had no real problems with the Endometrin other than the leaking.

I was originally on one a day and did it right before I went to bed. I had no leaking the next morning. But then I started on 2X a day and had to wear a liner for the morning. I also had pregnancy symptoms with them, but was pregnant so I don't know what caused the symptoms. I started at 1DPO and was on them until 12 weeks. I would go with the shots. Good luck!! Best switch I could have made. There is some messiness, but just wear a pantiliner. The PIO was causing painful lumpiness and bruising and my muscle was constantly sore.

A little messiness was nothing in comparison. Log in. My account. Baby Registry. The Bump Baby Registry. Getting Pregnant. Sign up for The Bump! Get weekly updates on baby and your body.

Start by selecting which of these best describes you! Success after IF New Discussion. September in Success after IF. Report 0 Reply to Post.Progesterone: IVF patients know it well. Because progesterone support is essential for getting, and staying, pregnant after fertility treatment.

Progesterone – the key facts for IVF patients

But some progesterone products work better than others. Some have side effects. Others are fiddly. A few are expensive.

The reason IVF patients need extra progesterone is purely chemical. After natural ovulation, the follicle that contained your egg turns into the corpus luteum. This is the trigger for progesterone, which makes your womb lining super-ready for the fertilised embryo. Your FSH injections produce multiple follicles.

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More medication e. Cetrotide puts the brakes on ovulation. Your trigger shot e. Ovitrelle take those brakes off and your eggs are released and retrieved. In short, IVF disrupts your natural progesterone function. So you need lots more of it. Progesterone facilitates implantation and safeguards your ongoing pregnancy. Donor-egg recipients need them too. In donor-egg treatmentyour ovaries are down-regulated. With your ovaries out of the picture, progesterone support is key.

One or two missed dose could spell disaster in those early weeks. Frozen embryo transfers FETs use progesterone too. Even in a natural-cycle FET i. Up till recently, you could take your progesterone three ways: orally, vaginally or intramuscularly. Each has its pros and cons, but oral and vaginal use is the most common.

Oral pills e. Utrogestan are okay, but they can cause sedative and nauseous side effects. Most clinics warn against oral use. Best to take your Utrogestan vaginally. Utrogestan is also the easiest form of progesterone to adjust dosage.

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Vaginal progesterone, in the form of gel Crinone or pessaries Cyclogestis often considered more effective.We strive to provide you with a high quality community experience. If you feel a message or content violates these standards and would like to request its removal please submit the following information and our moderating team will respond shortly. I'm 8 weeks pregnant with twins and have enough Endometrin progesterone to get me to Monday. My fertility clinic said that I don't need to purchase another round but doesn't 8 weeks seem too early to stop the progesterone?

It all depends on where your level is.

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My doctor said, as long as your levels are high enough, more progesterone won't do anything anyway. Maybe ask for periodic progesterone testing? I was told to stop my pessaries at 10 weeks. I had enough go take me to about 10w3d so I did that. I've done some Google medical school and it looks like the placenta picks up and takes over by 12 weeks or so.

I'm a little anxious about stopping without monitoring progesterone levels as I wean. I really hope the placenta is ready to do its thing! I am grateful it has helped me keep our bean, but damn I'm tired of gooey progesterone discharge mess.

I will be glad to be done in two weeks or so. I had an unmediated transfer and was on suppositories. I was told that I didn't need them after around 8 weeks but my counts were fine and the baby looked good.

I had a FET and have been on 3 pessaries a day. I've been told to continue to take them until 10 wks. Seems very scary to think that next week currently 9wks 3ds I'll be stopping. I have to admit I've been stressing at the thought of stopping them.Find answers to commonly asked questions about fertility and in vitro fertilization IVF.

If selected, your question will be answered and posted on this page. Conception is a complicated process, and there are many factors that can affect fertility.

For a detailed discussion, click here. A fertility specialist is also known as a reproductive endocrinologist. He or she will give both partners a physical examination to determine their general state of health and to identify underlying factors that may be affecting fertility. The doctor will also ask them about their sexual habits to get a better understanding of their conception issues. If no cause can be determined at this point, additional testing is usually recommended.

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For more information about diagnosis and testing, click here. Within a day, the eggs are fertilized and are then called embryos.


One or more of these embryos are then placed in the uterus. For more details on the procedure, click here. One important factor in achieving a successful pregnancy is to begin treatment immediately. As with many medical procedures, there is no guarantee of success. However, the earlier you begin treatment, the better your chances for a successful pregnancy because fertility declines with advancing age. See more facts about IVF here. For help finding a fertility specialist, click here.

The cost of a cycle can vary depending on a number of factors, but it is not inexpensive. Like other involved medical procedures, IVF requires highly trained professionals and high-end laboratories and equipment.

It is also possible that a cycle may need to be repeated, involving additional costs.It appears you have not yet Signed Up with our community.

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Subscribe To Infertility. My RE put me on Endometrin vag. Has anyone used this and noticed it working? The med is kind of weird, it looks like a tablet dry and hard not like a typical suppository. It makes me feel really dry down there sorry TMI. Anyone had the same problem on it? Pinkie, I had a mix up with meds leading up to this FET, but I found out I was supposed to be taking a pill vaginally I took an acutal progesterone suppository. But it sounds like it makes sense that it could cause dryness or irritation.

Just want to wish you luck in your 2WW!!!! But I have a friend who was doing IVF and she was taking hers vaginally.

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It is supposed to be closer to your uterus that way and won't have to wait to be digested. I imagine it would feel very awkward in your nether regions though. I use it for 2 weeks after every IUI until the beta shows negative and they will tell me to stop.

Embryo Transfer

Once I stop, it takes days before my AF will show so I guess it works on lengthening the luteal phase. I have 5 cycles of IUI and I conceived on my 5th one. I am on Endometrin from the day my beta showed positive until now and was told to continue it till the 9 weeks of pregnancy when the placenta is strong enough to produce lots of progesterone to prevent miscarriage.

Sometimes, its hard to put it in especially when you are dry down there and can cause irritation if you push the plastic injector too hard.

I lie down and relax and go slowly making sure it is all the way in. I find it even harder when I am at work as it is hard inserting it while sitting in the bathroom. I used it twice a day and sometimes forget the dose at night and I feel so guilty. Hi- sorry I haven't responded to any of the posts, my computer at home has been down. I read in a magazine that Endometrin worked really well in the IVF patients they were studying.

Do you find that the suppository leaks out after a while after it's been melted? Sometimes it feels like a gush of water coming out! After a while it will melt and come out in big chunks so you always need a pantyliner. I also noticed since I got pregnant and still using it that it doesnt come out as much as it used to be. Dont know if it is really absorbed more than before or my cervix is higher? Re: Endometrin suppositories- worth it?